Prkar2b^tm2Gsm
Targeted Allele Detail

Summary

• Symbol: Prkar2b^tm2Gsm
• Name: protein kinase, cAMP dependent regulatory, type II beta; targeted mutation 2, G Stanley McKnight
• MGI ID: MGI:3773428
• Synonyms: RIIbeta ^-, RIIbeta-neolox, RIIbetaneolox
• Gene: Prkar2b Location: Chr12:32008475-32111295 bp, - strand Genetic Position: Chr12, 13.74 cM, cytoband B1
• Alliance: Prkar2b^tm2Gsm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131039
• Parent Cell Line: REK3 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neomycin cassette was inserted in the 5 prime untranslated region of the gene. Homozygous mice show no expression of the gene and are phenotypically identical to homozygote Prkar2b^tm1Gsm mice. (J:131039)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkar2b Mutation: 27 strains or lines available

References

• Original: J:131039 Czyzyk TA, et al., Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):276-81
• All: 4 reference(s)