Hspa5^tm1Aoe
Targeted Allele Detail

Summary

• Symbol: Hspa5^tm1Aoe
• Name: heat shock protein 5; targeted mutation 1, Tomohiko Aoe
• MGI ID: MGI:3773635
• Synonyms: BiPdeltaKDEL
• Gene: Hspa5 Location: Chr2:34662102-34666541 bp, + strand Genetic Position: Chr2, 22.94 cM
• Alliance: Hspa5^tm1Aoe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131209
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region for the KDEL sequence was replaced with a floxed neo cassette that was subsequently removed by germ-line, cre-mediated recombination. (J:131209)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hspa5 Mutation: 39 strains or lines available

References

• Original: J:131209 Mimura N, et al., Aberrant quality control in the endoplasmic reticulum impairs the biosynthesis of pulmonary surfactant in mice expressing mutant BiP. Cell Death Differ. 2007 Aug;14(8):1475-85
• All: 5 reference(s)