Plcg2^tm1.1Kuro
Targeted Allele Detail

Summary

• Symbol: Plcg2^tm1.1Kuro
• Name: phospholipase C, gamma 2; targeted mutation 1.1, Tomohiro Kurosaki
• MGI ID: MGI:3773674
• Synonyms: PLCgamma2^-
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^tm1.1Kuro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131161
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• The exon encoding the PIP2 binding site was removed by cre-mediated recombination. (J:63744)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 74 strains or lines available

References

• Original: J:131161 Xu S, et al., Phospholipase Cgamma2 dosage is critical for B cell development in the absence of adaptor protein BLNK. J Immunol. 2006 Apr 15;176(8):4690-8
• All: 8 reference(s)