About   Help   FAQ
Foxp3tm1.1Mal
Targeted Allele Detail
Summary
Symbol: Foxp3tm1.1Mal
Name: forkhead box P3; targeted mutation 1.1, Bernard Malissen
MGI ID: MGI:3773675
Synonyms: FOXP3EGFP, Foxp3-GDL, Foxp3.LuciDTR-4, Foxp3tm1Mal
Gene: Foxp3  Location: ChrX:7445915-7461482 bp, + strand  Genetic Position: ChrX, 3.41 cM
Alliance: Foxp3tm1.1Mal page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131351
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsThe following sequences were inserted in the 3' UTR in exon 11: an IRES, the human diphtheria toxin receptor (HBEGF) cDNA coding region in-frame with the EGFP gene coding region, a loxP site, the mouse Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) promoter, the cre recombinase gene, a neomycin resistance gene cassette, and a second loxP site. Cre-mediated self-excision removed the cre+neo cassette in the male germline. The presence of the EGFP cassette does not interfeer with expression of the gene locus. EGFP expression occurs in Foxp3+ regulatory T cells. (J:131351)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:  58 strains or lines available
References
Original:  J:131351 Wang Y, et al., Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. J Immunol. 2008 Feb 1;180(3):1565-75
All:  66 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory