Foxp3tm1.1Mal
Targeted Allele Detail
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Symbol: |
Foxp3tm1.1Mal |
Name: |
forkhead box P3; targeted mutation 1.1, Bernard Malissen |
MGI ID: |
MGI:3773675 |
Synonyms: |
FOXP3EGFP, Foxp3-GDL, Foxp3.LuciDTR-4, Foxp3tm1Mal |
Gene: |
Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
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Alliance: |
Foxp3tm1.1Mal page
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Germline Transmission: |
Earliest citation of germline transmission:
J:131351
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Reporter) |
Mutation: |
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Insertion
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Mutation details: The following sequences were inserted in the 3' UTR in exon 11: an IRES, the human diphtheria toxin receptor (HBEGF) cDNA coding region in-frame with the EGFP gene coding region, a loxP site, the mouse Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) promoter, the cre recombinase gene, a neomycin resistance gene cassette, and a second loxP site. Cre-mediated self-excision removed the cre+neo cassette in the male germline. The presence of the EGFP cassette does not interfeer with expression of the gene locus. EGFP expression occurs in Foxp3+ regulatory T cells.
(J:131351)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:131351 Wang Y, et al., Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. J Immunol. 2008 Feb 1;180(3):1565-75 |
All: |
66 reference(s) |
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