Prrx1^tm1Bhr
Targeted Allele Detail

Summary

• Symbol: Prrx1^tm1Bhr
• Name: paired related homeobox 1; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:3773688
• Synonyms: Prx1^BatE
• Gene: Prrx1 Location: Chr1:163072688-163141279 bp, - strand Genetic Position: Chr1, 70.53 cM
• Alliance: Prrx1^tm1Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131364
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Targeting took place in ES cells homozyogus for the cre transgene Tg(Prm-cre)70Og, which expresses Cre recombinase only in haploid spermatids. The Carollia (bat) limb enhancer element was used to replace the endogenous mouse enhancer upstream of exon 1 and a floxed neo cassette was inserted into intron 1. Cre-mediated excision removed the neo cassette upon transmission from male chimeric mice. (J:131364)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prrx1 Mutation: 31 strains or lines available

References

• Original: J:131364 Cretekos CJ, et al., Regulatory divergence modifies limb length between mammals. Genes Dev. 2008 Jan 15;22(2):141-51
• All: 1 reference(s)