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Prrx1tm2Bhr
Targeted Allele Detail
Summary
Symbol: Prrx1tm2Bhr
Name: paired related homeobox 1; targeted mutation 2, Richard R Behringer
MGI ID: MGI:3773689
Synonyms: Prx1Enhdelta
Gene: Prrx1  Location: Chr1:163072688-163141279 bp, - strand  Genetic Position: Chr1, 70.53 cM
Alliance: Prrx1tm2Bhr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131364
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Mutation
description
Allele Type:    Targeted (Modified regulatory region)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTargeting took place in ES cells homozyogus for the cre transgene Tg(Prm-cre)70Og, which expresses Cre recombinase only in haploid spermatids. The endogenous mouse enhancer element upstream of exon 1 was deleted and a floxed neo cassette was inserted into intron 1. Cre-mediated excision removed the neo cassette upon transmission from male chimeric mice. (J:131364)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prrx1 Mutation:  31 strains or lines available
References
Original:  J:131364 Cretekos CJ, et al., Regulatory divergence modifies limb length between mammals. Genes Dev. 2008 Jan 15;22(2):141-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory