Ier3^tm1Raku
Targeted Allele Detail

Summary

• Symbol: Ier3^tm1Raku
• Name: immediate early response 3; targeted mutation 1, Rajiv Kumar
• MGI ID: MGI:3773690
• Synonyms: gly96/IEX-1^-, IEX-1 KO
• Gene: Ier3 Location: Chr17:36132605-36133803 bp, + strand Genetic Position: Chr17, 18.7 cM
• Alliance: Ier3^tm1Raku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131099
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a targeting vector replaced both exons and intron 1 with a neo resistance cassette. RT-PCR did not detect transcript in eight tissues tested. (J:131099)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ier3 Mutation: 11 strains or lines available

References

• Original: J:131099 Sommer SL, et al., Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene. J Appl Physiol. 2006 Feb;100(2):707-16
• All: 9 reference(s)