Cfi^tm1Mcp
Targeted Allele Detail

Summary

• Symbol: Cfi^tm1Mcp
• Name: complement component factor i; targeted mutation 1, Matthew C Pickering
• MGI ID: MGI:3773693
• Gene: Cfi Location: Chr3:129630432-129668978 bp, + strand Genetic Position: Chr3, 59.21 cM
• Alliance: Cfi^tm1Mcp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a neo cassette. The absence of protein was confrirmed by western blot analysis on serum extracts. (J:131403)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfi Mutation: 44 strains or lines available

References

• Original: J:131403 Rose KL, et al., Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice. J Clin Invest. 2008 Feb;118(2):608-18
• All: 2 reference(s)