Oprm1^tm1Jlw
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm1Jlw
• Name: opioid receptor, mu 1; targeted mutation 1, Jennifer L Whistler
• MGI ID: MGI:3773695
• Synonyms: RMOR, rMOR-R
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm1Jlw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131412
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The coding region of part of the cytoplasmic tail (FREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQ) within exon 3 was replaced with the sequence from the delta opioid peptide receptor (FRQLCRTPCGRQEPGSLRRPRQATTRERVTACTPSQ) and a floxed neo cassette. Expression of the receptor in homozygotes was similar to the endogenous receptor. (J:131412)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 54 strains or lines available

References

• Original: J:131412 Kim JA, et al., Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence. Curr Biol. 2008 Jan 22;18(2):129-35
• All: 3 reference(s)