Ednra^{tm3(Ednrb)Hku}
Targeted Allele Detail

Summary

• Symbol: Ednra^{tm3(Ednrb)Hku}
• Name: endothelin receptor type A; targeted mutation 3, Hiroki Kurihara
• MGI ID: MGI:3773700
• Synonyms: Endra^B
• Gene: Ednra Location: Chr8:78389658-78451081 bp, - strand Genetic Position: Chr8, 36.63 cM, cytoband C2
• Alliance: Ednra^{tm3(Ednrb)Hku} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131382
• Parent Cell Line: ATOM1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The coding region of Ednrb plus an frt-flanked puromycin resistance cassette was knocked into the neo cassette within exon 2 of Ednra^tm1Hku using RMCE. Expression of the knocked in allele was confirmed by RT-PCR of E9.5 mandible arches extracts. (J:131382)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ednra Mutation: 35 strains or lines available

References

• Original: J:131382 Sato T, et al., Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development. 2008 Feb;135(4):755-65
• All: 2 reference(s)