Myc^tm1Slek
Targeted Allele Detail

Summary

• Symbol: Myc^tm1Slek
• Name: myelocytomatosis oncogene; targeted mutation 1, Barry P Sleckman
• MGI ID: MGI:3773711
• Synonyms: c-Myc^G, GFP-c-Myc, Myc^eGFP, Myc^GFP, Myc^GIG
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm1Slek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131281
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Hypomorph, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette was inserted into intron 1 and subsequently removed through Cre-mediated recombination. A GFP cassette was inserted in-frame into exon 2 replacing the start codon. The expression of the fusion transcript and protein was confirmed by northern and western blot analysis at lower levels than normal. (J:131281, J:212391)

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 43 strains or lines available

References

• Original: J:131281 Huang CY, et al., Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse. Eur J Immunol. 2008 Feb;38(2):342-9
• All: 50 reference(s)