Tox^tm1.1Kay
Targeted Allele Detail

Summary

• Symbol: Tox^tm1.1Kay
• Name: thymocyte selection-associated high mobility group box; targeted mutation 1.1, Jonathan Kaye
• MGI ID: MGI:3773716
• Gene: Tox Location: Chr4:6686353-6991557 bp, - strand Genetic Position: Chr4, 3.04 cM
• Alliance: Tox^tm1.1Kay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131287
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. Transient expression of cre recombinase removed the neo cassette and exon 1. The absence of protein product was confirmed by western blot analysis on total thymocyte extracts. (J:131287)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tox Mutation: 39 strains or lines available

References

• Original: J:131287 Aliahmad P, et al., Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med. 2008 Jan 21;205(1):245-56
• All: 8 reference(s)