Myocd^tm1Msp
Targeted Allele Detail

Summary

• Symbol: Myocd^tm1Msp
• Name: myocardin; targeted mutation 1, Michael S Parmacek
• MGI ID: MGI:3773717
• Gene: Myocd Location: Chr11:65067387-65160815 bp, - strand Genetic Position: Chr11, 40.42 cM
• Alliance: Myocd^tm1Msp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo cassette with a 3' loxP site was inserted into intron 8 and an additional loxP site was inserted into intron 7. (J:131288)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myocd Mutation: 55 strains or lines available

References

• Original: J:131288 Huang J, et al., Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest. 2008 Feb;118(2):515-25
• All: 8 reference(s)