Myocd^tm1.1Msp
Targeted Allele Detail

Summary

• Symbol: Myocd^tm1.1Msp
• Name: myocardin; targeted mutation 1.1, Michael S Parmacek
• MGI ID: MGI:3773718
• Gene: Myocd Location: Chr11:65067387-65160815 bp, - strand Genetic Position: Chr11, 40.42 cM
• Alliance: Myocd^tm1.1Msp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ-line, cre-mediated recombination was used to remove exon 8. Authors state that this is a null allele because it recapitulates the phenotype of other null alleles. (J:131288)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myocd Mutation: 55 strains or lines available

References

• Original: J:131288 Huang J, et al., Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest. 2008 Feb;118(2):515-25
• All: 4 reference(s)