Myocd^tm1.1Msp
Targeted Allele Detail

Summary

• Symbol: Myocd^tm1.1Msp
• Name: myocardin; targeted mutation 1.1, Michael S Parmacek
• MGI ID: MGI:3773718
• Gene: Myocd Location: Chr11:65067387-65160815 bp, - strand Genetic Position: Chr11, 40.42 cM
• Alliance: Myocd^tm1.1Msp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ-line, cre-mediated recombination was used to remove exon 8. Authors state that this is a null allele because it recapitulates the phenotype of other null alleles. (J:131288)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Myocd^tm1.1Msp/Myocd^tm1.1Msp	involves: 129/Sv * C57BL/6
ht2  Disease Model	Myocd^em1Blk/Myocd^tm1.1Msp	involves: 129
cx3  Disease Model	Myocd^tm1.1Msp/mgb	involves: 129/Sv * FVB/N

Phenotypes:

Affected Systems	hm1	ht2	cx3
show or hide all annotated terms
cardiovascular system		N	√
cardiovascular system phenotype		N
patent ductus arteriosus			√
cellular			√
patent ductus arteriosus			√
mortality/aging	√	√	√
postnatal lethality, complete penetrance		√	√
embryonic lethality during organogenesis, complete penetrance	√
muscle		√
abnormal urinary bladder detrusor smooth muscle morphology		√
renal/urinary system		√	√
abnormal urinary bladder morphology		√	√
abnormal urinary bladder detrusor smooth muscle morphology		√
distended urinary bladder		√	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	ht2	cx3
congenital megabladder IDs congenital megabladder       DOID:0112014 OMIM:618719 Close	√	√

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myocd Mutation: 55 strains or lines available

References

• Original: J:131288 Huang J, et al., Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest. 2008 Feb;118(2):515-25
• All: 4 reference(s)