E2f8^tm1.1Gle
Targeted Allele Detail

Summary

• Symbol: E2f8^tm1.1Gle
• Name: E2F transcription factor 8; targeted mutation 1.1, Gustavo Leone
• MGI ID: MGI:3773724
• Gene: E2f8 Location: Chr7:48516177-48531344 bp, - strand Genetic Position: Chr7, 31.11 cM
• Alliance: E2f8^tm1.1Gle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131292
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3 and 4 were removed by germ-line, cre-mediated recombination. The absence of transcript expression was confirmed by real-time RT-PCR. (J:131292)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any E2f8 Mutation: 35 strains or lines available

References

• Original: J:131292 Li J, et al., Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell. 2008 Jan;14(1):62-75
• All: 5 reference(s)