Lepr^tm3(cre)Mgmj
Targeted Allele Detail

Summary

• Symbol: Lepr^tm3(cre)Mgmj
• Name: leptin receptor; targeted mutation 1, Martin G Myers, Jr
• MGI ID: MGI:3773731
• Synonyms: Lepr^Cre
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^tm3(cre)Mgmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131433
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Lepr^tm3(cre)Mgmj expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lepr (MGI:104993)

• Mutation details: Exon 18b was replaced with an exon 18b followed by a stop codon and an IRES-cre-3'UTR-neo cassette. The functionality of this knock in was confirmed by crosses to report mice. (J:131433)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lepr (mouse) Summary of all recombinase alleles driven by Lepr. Comparative matrix view of recombinase activities Alliance mouse Lepr gene page

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:131433 Leshan RL, et al., Leptin receptor signaling and action in the central nervous system. Obesity (Silver Spring). 2006 Aug;14 Suppl 5:208S-212S
• All: 68 reference(s)