Nkx2-5^tm6Rph
Targeted Allele Detail

Summary

• Symbol: Nkx2-5^tm6Rph
• Name: NK2 homeobox 5; targeted mutation 6, Richard P Harvey
• MGI ID: MGI:3773737
• Synonyms: Nkx2-5^lacZdeltaH
• Gene: Nkx2-5 Location: Chr17:27057638-27063962 bp, - strand Genetic Position: Chr17, 13.6 cM
• Alliance: Nkx2-5^tm6Rph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131435
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1, intron 1 and part 2 were replaced with a lacZ cassette and a floxed hygro cassette. Exon 2 contains a small deletion of nucleotides encoding for amino acids 141 to 184, a homeobox. The hygro cassette was removed by subsequent cre-recombination. (J:131435)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-5 Mutation: 21 strains or lines available

References

• Original: J:131435 Elliott DA, et al., A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery. Development. 2006 Apr;133(7):1311-22
• All: 5 reference(s)