Tg(Tcra,Tcrb)HRCAll
Transgene Detail

Summary

• Symbol: Tg(Tcra,Tcrb)HRCAll
• Name: transgene insertion HRC, James P Allison
• MGI ID: MGI:3773741
• Synonyms: 6B1-6 TCR, HRC TCR
• Transgene: Tg(Tcra,Tcrb)HRCAll Location: unknown
• Alliance: Tg(Tcra,Tcrb)HRCAll page

Transgene origin

• Strain of Origin: either: C57BL/6 or (CBA x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra,Tcrb)HRCAll expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Rearranged Valpha2-SGTGGYKV TCRalpha and Vbeta8.3-SGTGGSAETL TCRbeta chains were cloned from a population of CD8⁺ T cells that recognizes a 17-mer peptide from the C-terminus of Histone 4 family members presented on H2-K^b. The recombined gene segments were placed in a TCR expression vector and injected into blastocytes. This founder line is characterized by "complete" expression of the transgenic TCR with 98% of CD8⁺ T cells expressing the transgenic TCR. (J:131347)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:131347 Savage PA, et al., Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes. Science. 2008 Jan 11;319(5860):215-20
• All: 2 reference(s)