Adora2b^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Adora2b^tm1Dgen
• Name: adenosine A2b receptor; targeted mutation 1, Deltagen
• MGI ID: MGI:3773754
• Synonyms: A2BAR^-, A2BKO
• Gene: Adora2b Location: Chr11:62139810-62157278 bp, + strand Genetic Position: Chr11, 37.96 cM, cytoband B2
• Alliance: Adora2b^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131444
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A fragment from 112 bp to 267 bp of the coding region was replaced with an IRES-lacZ and neo cassette. The absence of transcript expression was confirmed by real-time RT-PCR on cardiac tissue extracts. This allele is also a null allele. (J:131444)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adora2b Mutation: 20 strains or lines available

References

• Original: J:131444 Eckle T, et al., Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation. 2007 Mar 27;115(12):1581-90
• All: 37 reference(s)