Hsd17b2^tm1Mpo
Targeted Allele Detail

Summary

• Symbol: Hsd17b2^tm1Mpo
• Name: hydroxysteroid (17-beta) dehydrogenase 2; targeted mutation 1, Matti Poutanen
• MGI ID: MGI:3773836
• Gene: Hsd17b2 Location: Chr8:118428643-118485766 bp, + strand Genetic Position: Chr8, 64.82 cM
• Alliance: Hsd17b2^tm1Mpo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131329
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 4. The absence of transcript was confirmed by northern blot analysis on kidney and liver extracts. (J:131329)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd17b2 Mutation: 13 strains or lines available

References

• Original: J:131329 Rantakari P, et al., Placenta Defects and Embryonic Lethality Resulting from Disruption of Mouse Hydroxysteroid (17-{beta}) Dehydrogenase 2 Gene. Mol Endocrinol. 2008 Mar;22(3):665-75
• All: 2 reference(s)