Tcra/Tcrd^{tm1.1(Tcra)Rsky}
Targeted Allele Detail

Summary

• Symbol: Tcra/Tcrd^{tm1.1(Tcra)Rsky}
• Name: T cell receptor alpha chain; targeted mutation 1.1, Klaus Rajewsky
• MGI ID: MGI:3773839
• Synonyms: HYalpha^Idelta
• Gene: Tcra Location: Chr14:52665424-54461655 bp, + strand Genetic Position: Chr14, cytoband D1-D2

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81564
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intergenic deletion
• Mutation details: Mice carrying the Tcra^{tm1(Tcra)Rsky} allele were crossed with a Cre deleter strain to remove the Tcrd locus and allow expression of the knocked in Tcra. This Tcra partly encodes for a T cell receptor that recognizes the HY male antigen. (J:81564)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcra Mutation: 101 strains or lines available

References

• Original: J:81564 Buch T, et al., Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity. 2002 May;16(5):707-18
• All: 5 reference(s)