Zbtb7b^tm1Tani
Targeted Allele Detail

Summary

• Symbol: Zbtb7b^tm1Tani
• Name: zinc finger and BTB domain containing 7B; targeted mutation 1, Ichiro Taniuchi
• MGI ID: MGI:3774002
• Synonyms: Th-POK-GFP, Th-POK^GFP
• Gene: Zbtb7b Location: Chr3:89284953-89300976 bp, - strand Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
• Alliance: Zbtb7b^tm1Tani page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131081
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was replaced with GFP and a floxed neo cassette. Transient expression of cre-recombinase removed the neo cassette leaving a single loxP site behind. (J:131081, J:141142)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zbtb7b Mutation: 26 strains or lines available

References

• Original: J:131081 Setoguchi R, et al., Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science. 2008 Feb 8;319(5864):822-5
• All: 19 reference(s)