Npepps^tm1Klr
Targeted Allele Detail

Summary

• Symbol: Npepps^tm1Klr
• Name: aminopeptidase puromycin sensitive; targeted mutation 1, Kenneth L Rock
• MGI ID: MGI:3774016
• Synonyms: PSA^-
• Gene: Npepps Location: Chr11:97096668-97171464 bp, - strand Genetic Position: Chr11, 60.95 cM
• Alliance: Npepps^tm1Klr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131502
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 9 were replaced with a lacZ-neo cassette. This deletion includes half of the enzymatic core encoded in exon 9 and 10. The presence of a truncated transcript lacking exons 10 and 11 was confirmed by RT-PCR analysis. (J:131502)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npepps Mutation: 124 strains or lines available

References

• Original: J:131502 Towne CF, et al., Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections. J Immunol. 2008 Feb 1;180(3):1704-12
• All: 1 reference(s)