Xbp1^tm2Glm
Targeted Allele Detail

Summary

• Symbol: Xbp1^tm2Glm
• Name: X-box binding protein 1; targeted mutation 2, Laurie H Glimcher
• MGI ID: MGI:3774017
• Synonyms: XBP-1^flox
• Gene: Xbp1 Location: Chr11:5470659-5475893 bp, + strand Genetic Position: Chr11, 3.61 cM
• Alliance: Xbp1^tm2Glm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131028
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Cre-mediated recombination of Xbp1^tm3Glm removed the neo cassette and left exon 2 floxed. (J:131028)

Disease models

Expression

In Mice Carrying this Mutation:	38 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xbp1 Mutation: 29 strains or lines available

References

• Original: J:131028 Hetz C, et al., Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):757-62
• All: 111 reference(s)