Eomes^tm1Rob
Targeted Allele Detail

Summary

• Symbol: Eomes^tm1Rob
• Name: eomesodermin; targeted mutation 1, Elizabeth J Robertson
• MGI ID: MGI:3774027
• Synonyms: Eomes^CA, Tbr2/Eomes^CA
• Gene: Eomes Location: Chr9:118307259-118315176 bp, + strand Genetic Position: Chr9, 70.21 cM, cytoband F3
• Alliance: Eomes^tm1Rob page

Eomes^tm1Rob/Eomes^tm2.1Rob Edil3^{Tg(Sox2-cre)1Amc}/0 embryos fail to form the mesoderm cell layer and are blocked in gastrulation

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131055
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 5-6 and additional loxP site was inserted into intron 1-2. This resulted in the floxing of exons 2 through 5. Transient Cre expression was used to removed the neo cassette. (J:131055)

Expression

In Mice Carrying this Mutation:	10 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eomes Mutation: 44 strains or lines available

References

• Original: J:131055 Arnold SJ, et al., Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development. 2008 Feb;135(3):501-11
• All: 16 reference(s)