Eomes^tm1.1Rob
Targeted Allele Detail

Summary

• Symbol: Eomes^tm1.1Rob
• Name: eomesodermin; targeted mutation 1.1, Elizabeth J Robertson
• MGI ID: MGI:3774028
• Synonyms: Eomes^N
• Gene: Eomes Location: Chr9:118307259-118315176 bp, + strand Genetic Position: Chr9, 70.21 cM, cytoband F3
• Alliance: Eomes^tm1.1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131055
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Heterozygous Eomes^tm1Rob males were crossed to females expressing a cre transgene that is active in the female germline functioning as a general deleter to remove exons 2-5, thus creating a null allele. (J:131055)

Expression

In Mice Carrying this Mutation:	14 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eomes Mutation: 44 strains or lines available

References

• Original: J:131055 Arnold SJ, et al., Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development. 2008 Feb;135(3):501-11
• All: 10 reference(s)