Chrna10^tm1Jbou
Targeted Allele Detail

Summary

• Symbol: Chrna10^tm1Jbou
• Name: cholinergic receptor, nicotinic, alpha polypeptide 10; targeted mutation 1, Jim Boulter
• MGI ID: MGI:3774038
• Synonyms: alpha10^-, Chrna10^tm1Bedv
• Gene: Chrna10 Location: Chr7:101760473-101766035 bp, - strand Genetic Position: Chr7, 54.71 cM
• Alliance: Chrna10^tm1Jbou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130585
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 and intron 3 were replaced with a floxed neo cassette. The absence of transcript expression was confirmed by qRT-PCR. (J:130585)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Chrna10^tm1Jbou/Chrna10^tm1Jbou	Not Specified

Phenotypes:

Affected Systems	hm1
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hearing/vestibular/ear	√
hearing/vestibular/ear phenotype	N
abnormal cochlear hair cell morphology	√
abnormal cochlear IHC efferent innervation pattern	√
abnormal cochlear OHC efferent innervation pattern	√
abnormal cochlear hair cell physiology	√
abnormal cochlear inner hair cell physiology	√
abnormal cochlear outer hair cell physiology	√
abnormal distortion product otoacoustic emission	√
nervous system	√
abnormal cochlear hair cell morphology	√
abnormal cochlear IHC efferent innervation pattern	√
abnormal cochlear OHC efferent innervation pattern	√
abnormal cochlear hair cell physiology	√
abnormal cochlear inner hair cell physiology	√
abnormal cochlear outer hair cell physiology	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chrna10 Mutation: 18 strains or lines available

References

• Original: J:130585 Vetter DE, et al., The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20594-9
• All: 8 reference(s)