Chrna10^tm1Jbou
Targeted Allele Detail

Summary

• Symbol: Chrna10^tm1Jbou
• Name: cholinergic receptor, nicotinic, alpha polypeptide 10; targeted mutation 1, Jim Boulter
• MGI ID: MGI:3774038
• Synonyms: alpha10^-, Chrna10^tm1Bedv
• Gene: Chrna10 Location: Chr7:101760473-101766035 bp, - strand Genetic Position: Chr7, 54.71 cM
• Alliance: Chrna10^tm1Jbou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130585
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 and intron 3 were replaced with a floxed neo cassette. The absence of transcript expression was confirmed by qRT-PCR. (J:130585)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chrna10 Mutation: 18 strains or lines available

References

• Original: J:130585 Vetter DE, et al., The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20594-9
• All: 8 reference(s)