Ubb^tm1Rrk
Targeted Allele Detail

Summary

• Symbol: Ubb^tm1Rrk
• Name: ubiquitin B; targeted mutation 1, Ron R Kopito
• MGI ID: MGI:3774112
• Gene: Ubb Location: Chr11:62442329-62444037 bp, + strand Genetic Position: Chr11, 38.46 cM
• Alliance: Ubb^tm1Rrk page

Adult-onset obesity in Ubb^tm1Rrk/Ubb^tm1Rrk mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130361
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding exon was replaced with a promoterless GFP-puro fusion cassette. Expression of the GFP was confirmed by qRT-PCR. The authors state that this is a null allele. (J:130361)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ubb Mutation: 18 strains or lines available

References

• Original: J:130361 Ryu KY, et al., The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol Cell Biol. 2008 Feb;28(3):1136-46
• All: 12 reference(s)