Irak4^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Irak4^m1Btlr
• Name: interleukin-1 receptor-associated kinase 4; mutation 1, Bruce Beutler
• MGI ID: MGI:3774129
• Synonyms: otiose
• Gene: Irak4 Location: Chr15:94441495-94466198 bp, + strand Genetic Position: Chr15, 48.55 cM, cytoband F1
• Alliance: Irak4^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The otiose mutation, which was identified in an ENU mutagenesis screen for mutants with altered responses to Toll-like receptor (TLR) ligands, corresponds to a T to C transition at nucleotide position 1095 of the gene, in exon 9 of 12 total exons. No immunoreactive protein is detected by western blot analysis of mutant macrophages, and immunoprecipitated protein from mutant macrophages exhibits no kinase activity in vitro. (J:86521, J:133271)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Irak4 Mutation: 32 strains or lines available

References

• Original: J:133271 Berger M, et al., Otiose is an allele of Irak4 and has TLR-signaling defects. MGI Direct Data Submission. 2008
• All: 7 reference(s)