Alx4^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Alx4^m1Btlr
• Name: aristaless-like homeobox 4; mutation 1, Bruce Beutler
• MGI ID: MGI:3774135
• Synonyms: goofy
• Gene: Alx4 Location: Chr2:93472779-93511686 bp, + strand Genetic Position: Chr2, 51.62 cM
• Alliance: Alx4^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The goofy mutation corresponds to an A to G transition at nucleotide position 1010 (Genbank Accession NM_007442), in exon 4 of 5 total exons, that results in replacement of histidine by arginine at amino acid position 272 of the protein (H272R).
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Alx4 Mutation: 21 strains or lines available

References

• Original: J:132742 Du X, et al., Goofy, a mouse Alx4 mutant with anomalies of craniofacial and digit development and hair growth. MGI Direct Data Submission. 2008
• All: 1 reference(s)