Asph^tm1Egk
Targeted Allele Detail

Summary

• Symbol: Asph^tm1Egk
• Name: aspartate-beta-hydroxylase; targeted mutation 1, Evangelia G Kranias
• MGI ID: MGI:3774139
• Synonyms: Jct^-
• Gene: Asph Location: Chr4:9449085-9669344 bp, - strand Genetic Position: Chr4, 4.17 cM, cytoband A1
• Alliance: Asph^tm1Egk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130155
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on heart extracts. (J:130155)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asph Mutation: 61 strains or lines available

References

• Original: J:130155 Yuan Q, et al., Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation. 2007 Jan 23;115(3):300-9
• All: 5 reference(s)