Tlr9^m4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr9^m4Btlr
• Name: toll-like receptor 9; mutation 4, Bruce Beutler
• MGI ID: MGI:3774140
• Synonyms: CpG5, Tlr9^CpG5, unmethylated CpG-oligodeoxynucleotide unresponsive 5
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^m4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutant phenotype, discovered in an ENU mutagenesis screen for impaired response of peritoneal macrophages to Toll-like receptor (TLR) ligands, is due to a T-to-C transition at nucleotide position 1284 (Genbank Accession NM_031178) in the second of two exons. It results in replacement of leucine by proline at amino acid position 393 (L393P), the initial leucine in the fourteenth extracellular leucine-rich repeat of the receptor's ectodomain. (J:132489)
• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 66 strains or lines available

Notes

The inheritance of the mutant phenotype is probably semidominant, like that of other Tlr9 mutations; however, homozygous mutants have not been examined.

References

• Original: J:132489 Xiao N, et al., The CpG5 mutation of Tlr9 specifically impairs immune response to unmethylated CpG oligonucleotides. MGI Direct Data Submission. 2008
• All: 1 reference(s)