Rr96^tm1.1Yzo
Targeted Allele Detail

Summary

• Symbol: Rr96^tm1.1Yzo
• Name: regulatory region 96; targeted mutation 1.1, Yong-Rui Zou
• MGI ID: MGI:3774142
• Synonyms: Cd4^deltaLS, Cd4^tm1.1Yzo, sil^-
• Gene: Rr96 Location: Chr6:124862841-124863329 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr96^tm1.1Yzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130559
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted downstream of Cd4 intronic silencer S4 and a loxP site flanked neomycin resistance gene cassette upstream. Cre-mediated recombination was used to delete the silencer and the neo cassette. (J:130559)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr96 Mutation: 0 strains or lines available

References

• Original: J:130559 Zou YR, et al., Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat Genet. 2001 Nov;29(3):332-6
• All: 4 reference(s)