Mitf^tm1.1Arnh
Targeted Allele Detail

Summary

• Symbol: Mitf^tm1.1Arnh
• Name: melanogenesis associated transcription factor; targeted mutation 1.1, Heinz Arnheiter
• MGI ID: MGI:3774160
• Synonyms: Mitf S73A-delta-neo
• Gene: Mitf Location: Chr6:97784013-97998310 bp, + strand Genetic Position: Chr6, 45.05 cM
• Alliance: Mitf^tm1.1Arnh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130168
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Mitf^tm1Arnh mice were crossed with a Cre deleter strain to remove the floxed neomycin cassette from germline cells. Removal of the neomycin selection cassette was confirmed by genomic PCR. Coat pigmentation is more enhanced in homozygotes compared to homozgyotes of the Mitf^tm1Arnh parental strain. (J:130168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mitf Mutation: 74 strains or lines available

References

• Original: J:130168 Bismuth K, et al., An unstable targeted allele of the mouse mitf gene with a high somatic and germline reversion rate. Genetics. 2008 Jan;178(1):259-72
• All: 1 reference(s)