Cstf2t^tm1Ccma
Targeted Allele Detail

Summary

• Symbol: Cstf2t^tm1Ccma
• Name: cleavage stimulation factor, 3' pre-RNA subunit 2, tau; targeted mutation 1, Clinton C MacDonald
• MGI ID: MGI:3774168
• Synonyms: Cstf2t^-, Cstf2t^tm1(Neo)
• Gene: Cstf2t Location: Chr19:31060241-31063992 bp, + strand Genetic Position: Chr19, 25.94 cM
• Alliance: Cstf2t^tm1Ccma page

Lesions in Cstf2t^tm1Ccma/Cstf2t^tm1Ccma mouse testes

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130584
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was replaced with a neo cassette. The absence of protein was confirmed by western blot analysis on testis extracts. (J:130584)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cstf2t Mutation: 23 strains or lines available

References

• Original: J:130584 Dass B, et al., Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20374-9
• All: 6 reference(s)