Gt(ROSA)26Sor^tm3Dym
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm3Dym
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Susan Dymecki
• MGI ID: MGI:3774184
• Synonyms: R26::FLAP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm3Dym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128980
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing a splice acceptor, frt-flanked neo cassette, floxed IRES-EGFP with a farnesyl modification, and human placental alkaline phosphatase was inserted into the ROSA locus. Expression of the membrane-bound EGFP occurs after flp-mediated excision and expression of the human placental alkaline phosphatase occurs after both flp- and cre-mediated recombination. (J:128980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:128980 Awatramani R, et al., Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet. 2003 Sep;35(1):70-5
• All: 1 reference(s)