Akr1c18^tm1Mni
Targeted Allele Detail

Summary

• Symbol: Akr1c18^tm1Mni
• Name: aldo-keto reductase family 1, member C18; targeted mutation 1, Masugi Nishihara
• MGI ID: MGI:3774264
• Synonyms: 20alpha-HSD^-
• Gene: Akr1c18 Location: Chr13:4182614-4200645 bp, - strand Genetic Position: Chr13, 2.31 cM
• Alliance: Akr1c18^tm1Mni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129608
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced with an IRES-EGFP and neo cassette. The absence of protein product was confirmed by western blot analysis. This is a null allele. (J:129608)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Akr1c18 Mutation: 29 strains or lines available

References

• Original: J:129608 Ishida M, et al., Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene. J Reprod Dev. 2007 Jun;53(3):499-508
• All: 2 reference(s)