Wdtc1^{Gt(RRF015)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Wdtc1^{Gt(RRF015)Byg}
• Name: WD and tetratricopeptide repeats 1; gene trap RRF015, BayGenomics
• MGI ID: MGI:3774270
• Synonyms: Adp^-
• Gene: Wdtc1 Location: Chr4:133019770-133080792 bp, - strand Genetic Position: Chr4, 66.25 cM
• Alliance: Wdtc1^{Gt(RRF015)Byg} page

Mutation origin

• Mutant Cell Line: RRF015
• Germline Transmission: Earliest citation of germline transmission: J:129966
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: A gene trap segment containing a splice acceptor and a LacZ-neo cassette was inserted between the first and second coding exons. The predicted transcript would only encode 15 amino acids. (J:129966)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRF015	CC249343 ; (MGI Seq Detail)	5' RACE	Chr4:133051140-133080205 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  65 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdtc1 Mutation: 72 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:129966 Suh JM, et al., Adipose is a conserved dosage-sensitive antiobesity gene. Cell Metab. 2007 Sep;6(3):195-207
• All: 2 reference(s)