Nr1h4^tm1.1Gonz
Targeted Allele Detail

Summary

• Symbol: Nr1h4^tm1.1Gonz
• Name: nuclear receptor subfamily 1, group H, member 4; targeted mutation 1.1, Frank Gonzalez
• MGI ID: MGI:3774280
• Synonyms: Fxr^fl
• Gene: Nr1h4 Location: Chr10:89290096-89369447 bp, - strand Genetic Position: Chr10, 44.98 cM
• Alliance: Nr1h4^tm1.1Gonz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64792
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in the intron 5' to the last exon and a loxP-flanked neomycin cassette was inserted 3' to the last exon. (J:64792)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h4 Mutation: 43 strains or lines available

References

• Original: J:64792 Sinal CJ, et al., Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell. 2000 Sep 15;102(6):731-44
• All: 25 reference(s)