Ntrk2^tm1Mini
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm1Mini
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 1, Liliana Minichiello
• MGI ID: MGI:3774320
• Synonyms: trkB^PLC
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm1Mini page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130626
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: A cDNA encoding the open reading frame with an A to T transversion at position 2958 that resulted in an amino acid substitution of phenylalanine for tyrosine at position 816 (Y816F) was inserted into the coding exon. A floxed neo cassette was also inserted downstream of the cDNA but was removed by subsequent germ-line, cre-mediated recombination. The amino acid substitution occures within the PLCgamma site. (J:130626)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:130626 Minichiello L, et al., Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron. 2002 Sep 26;36(1):121-37
• All: 8 reference(s)