Flcn^tm1.1Lss
Targeted Allele Detail

Summary

• Symbol: Flcn^tm1.1Lss
• Name: folliculin; targeted mutation 1.1, Laura S Schmidt
• MGI ID: MGI:3774416
• Synonyms: BHD^d
• Gene: Flcn Location: Chr11:59682234-59700842 bp, - strand Genetic Position: Chr11, 37.79 cM
• Alliance: Flcn^tm1.1Lss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130978
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 7 was removed by germ-line, cre-mediated recombination. Deletion of exon 7 results in a frame shift and premature termination. This allele is expected to be null. (J:130978)

Disease models

Expression

In Mice Carrying this Mutation:	119 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flcn Mutation: 42 strains or lines available

References

• Original: J:130978 Baba M, et al., Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst. 2008 Jan 16;100(2):140-54
• All: 4 reference(s)