Ankrd26^Gt(XK525)Byg
Gene trapped Allele Detail

Summary

• Symbol: Ankrd26^Gt(XK525)Byg
• Name: ankyrin repeat domain 26; gene trap XK525, BayGenomics
• MGI ID: MGI:3774418
• Gene: Ankrd26 Location: Chr6:118478269-118539187 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband F1
• Alliance: Ankrd26^Gt(XK525)Byg page

Ankrd26^Gt(XK525)Byg/Ankrd26^Gt(XK525)Byg mice (right) are extremely large and obese

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: XK525
• Germline Transmission: Earliest citation of germline transmission: J:130984
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: A beta-geo cassette was inserted into intron 24. This disrupted the formation of the coiled coil motif. Expression of a shortened fusion protein was confirmed by western blot analysis. (J:130984)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XK525	CC248789 ; (MGI Seq Detail)	5' RACE	Chr6:118499901-118500317 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  3 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ankrd26 Mutation: 69 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:130984 Bera TK, et al., A model for obesity and gigantism due to disruption of the Ankrd26 gene. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):270-5
• All: 5 reference(s)