Foxa2^{tm2(cre/Esr1*)Moon}
Targeted Allele Detail

Summary

• Symbol: Foxa2^{tm2(cre/Esr1*)Moon}
• Name: forkhead box A2; targeted mutation 2, Anna M Moon
• MGI ID: MGI:3774419
• Synonyms: Foxa2^mcm-neo, Foxa2^{tm2(cre/Esr1*)Moon}
• Gene: Foxa2 Location: Chr2:147884797-147888889 bp, - strand Genetic Position: Chr2, 73.38 cM
• Alliance: Foxa2^{tm2(cre/Esr1*)Moon} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130990
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph, Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Foxa2^{tm2(cre/Esr1*)Moon} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxa2 (MGI:1347476)

• Mutation details: An IRES followed by a mouse Esr1 binding domain fused to both sides of cre and an frt-flanked neo cassette was inserted in frame following the stop codon in exon 3. This allele is a hypomorph. (J:130990)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxa2 (mouse) Summary of all recombinase alleles driven by Foxa2. Alliance mouse Foxa2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxa2 Mutation: 28 strains or lines available

References

• Original: J:130990 Park EJ, et al., System for tamoxifen-inducible expression of cre-recombinase from the Foxa2 locus in mice. Dev Dyn. 2008 Feb;237(2):447-53
• All: 2 reference(s)