Ighm^tm4Bgmn
Targeted Allele Detail

Summary

• Symbol: Ighm^tm4Bgmn
• Name: immunoglobulin heavy constant mu; targeted mutation 4, Marianne Bruggemann
• MGI ID: MGI:3774510
• Synonyms: muNR3
• Gene: Ighm Location: Chr12:113382446-113386350 bp, - strand Genetic Position: Chr12, 62.1 cM, cytoband F1-2
• Alliance: Ighm^tm4Bgmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131633
• Parent Cell Line: ZX3 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette was inserted in the anti-sense direction at the BglII and BamHI sites in the constant region 1 to 2 (Cmu1-2). This results in the loss of the constant regions 1 and 2 and a truncation of the produced protein as confirmed by western blot analysis. (J:131633)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighm Mutation: 56 strains or lines available

References

• Original: J:131633 Zou X, et al., Truncation of the mu heavy chain alters BCR signalling and allows recruitment of CD5+ B cells. Int Immunol. 2001 Dec;13(12):1489-99
• All: 1 reference(s)