Sh2d1a^tm2Vei
Targeted Allele Detail

Summary

• Symbol: Sh2d1a^tm2Vei
• Name: SH2 domain containing 1A; targeted mutation 2, Andre Veillette
• MGI ID: MGI:3774546
• Synonyms: sap^fl
• Gene: Sh2d1a Location: ChrX:41591442-41610974 bp, + strand Genetic Position: ChrX, 23.2 cM, cytoband A5
• Alliance: Sh2d1a^tm2Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131618
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. The neo cassette ws removed by flp-mediated recombination. (J:131618)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d1a Mutation: 11 strains or lines available

References

• Original: J:131618 Veillette A, et al., SAP expression in T cells, not in B cells, is required for humoral immunity. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1273-8
• All: 2 reference(s)