Cerk^tm1Fbor
Targeted Allele Detail

Summary

• Symbol: Cerk^tm1Fbor
• Name: ceramide kinase; targeted mutation 1, Frederic Bornancin
• MGI ID: MGI:3774547
• Gene: Cerk Location: Chr15:86023329-86070342 bp, - strand Genetic Position: Chr15, 40.52 cM
• Alliance: Cerk^tm1Fbor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131522
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 5 were replaced with a floxed neo cassette. The lack of transcript expression was confirmed by real-time PCR. (J:131522)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cerk Mutation: 26 strains or lines available

References

• Original: J:131522 Graf C, et al., Neutropenia with Impaired Immune Response to Streptococcus pneumoniae in Ceramide Kinase-Deficient Mice. J Immunol. 2008 Mar 1;180(5):3457-66
• All: 7 reference(s)