Atf2^tm3Nicj
Targeted Allele Detail

Summary

• Symbol: Atf2^tm3Nicj
• Name: activating transcription factor 2; targeted mutation 3, Nic Jones
• MGI ID: MGI:3774771
• Synonyms: ATF2^f
• Gene: Atf2 Location: Chr2:73646853-73722983 bp, - strand Genetic Position: Chr2, 43.86 cM
• Alliance: Atf2^tm3Nicj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123909
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 8 and 9 encoding the DNA-binding domain and a portion of the leucine zipper were flanked by loxP sites. Gene expression was comparable to wild-type in numerous tissues. (J:131564)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Atf2^tm3Nicj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf2 Mutation: 89 strains or lines available

References

• Original: J:123909 Breitwieser W, et al., Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
• All: 10 reference(s)