Tg(ACTA1-SMN)63Ahmb
Transgene Detail

Summary

• Symbol: Tg(ACTA1-SMN)63Ahmb
• Name: transgene insertion 63, Arthur H M Burghes
• MGI ID: MGI:3774939
• Synonyms: HSA63-SMN, HSA69-SMN
• Transgene: Tg(ACTA1-SMN)63Ahmb Location: unknown
• Alliance: Tg(ACTA1-SMN)63Ahmb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-SMN)63Ahmb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SMN1 (6606)

  Smn1	(MGI:109257)

• Mutation details: he HSA-SMN transgene was designed with the human alpha-skeletal actin (HSA or ACTA1) promoter region, splice acceptor site from the SV40 VP1 intron, full-length human SMN cDNA (containing exons 1-8), and two SV40 polyA signals. Mice from founder line 63 (HSA63-SMN) were found to have 5 copies of the transgene. (J:97103, J:131663)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:131663 Gavrilina TO, et al., Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect. Hum Mol Genet. 2008 Apr 15;17(8):1063-75
• All: 3 reference(s)