Mapk8^tm1Rjd
Targeted Allele Detail

Summary

• Symbol: Mapk8^tm1Rjd
• Name: mitogen-activated protein kinase 8; targeted mutation 1, Roger J Davis
• MGI ID: MGI:3775057
• Synonyms: Jnk1^LoxP, Mapk8^tm2Flv
• Gene: Mapk8 Location: Chr14:33099855-33169115 bp, - strand Genetic Position: Chr14, 20.22 cM, cytoband B
• Alliance: Mapk8^tm1Rjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131766
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of the exon containing the TPY activation loop and an aditional loxP site was inserted downstream of that exon. The neo cassette was removed by cre-mediated recombination (no details given). (J:131766)

Disease models

Expression

In Mice Carrying this Mutation:

80 assay results 2 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Mapk8^tm1Rjd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk8 Mutation: 74 strains or lines available

References

• Original: J:131766 Das M, et al., Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15759-64
• All: 48 reference(s)