Del(14Ltb4r2-Ltb4r1)1Bodd
Targeted Allele Detail

Summary

• Symbol: Del(14Ltb4r2-Ltb4r1)1Bodd
• Name: deletion, Chr 14, Bodduluri Haribabu 1
• MGI ID: MGI:3775059
• Synonyms: BLT1/BLT2^-, Del1Bodd, Ltb4r1/Ltb4r2^tm2Bodd
• Gene: Del(14Ltb4r2-Ltb4r1)1Bodd Location: unknown Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131779
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(14Ltb4r2-Ltb4r1)1Bodd involves 2 genes/genome features (Ltb4r2, Ltb4r1) View all
• Mutation details: 6 Kb of the coding region and the untranscribed region between both open reading frames were replaced with an EGFP-neo cassette. The absence of transcript from either open reading frame was confirmed by northern blot analysis on spleen, liver, neutrophil and macrophage extracts. (J:131779)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(14Ltb4r2-Ltb4r1)1Bodd Mutation: 1 strain or line available

References

• Original: J:131779 Shao WH, et al., Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: a critical role for BLT1 in collagen-induced arthritis in mice. J Immunol. 2006 May 15;176(10):6254-61
• All: 3 reference(s)